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The principal cytochrome P450 isoenzyme associated seems for being CYP2E1, with CYP1A2 and CYP3A4 as additional pathways. Approximately 85% of an oral dose appears from the urine within 24 hours of administration, most given that the glucuronide conjugate, with little quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity d